Title: The Quantitative Analysis of MMP-9 in Kidney of Diabetic Rats
Abstract:Objective To investigate the expression of matrix metalloproteinase-9(MMP-9)in kidney of diabetic rats.Methods 20 adult SD rats were randomly divided into normal control group(NC)and diabetic model gr...Objective To investigate the expression of matrix metalloproteinase-9(MMP-9)in kidney of diabetic rats.Methods 20 adult SD rats were randomly divided into normal control group(NC)and diabetic model group(DM).After diabetic model rats were induced by streptozotocin(STZ),the morphological changes were observed through the light microscope and immunohistochemical staining was employed to detect the expression of MMP-9 in kidney and analyzed with image analysis system.Results The morphological changes of the glomeluri of diabetic rats were obvious,but with the normal structure of the normal rats.The expression of MMP-9 in diabetic kidneys was significantly lower than that in normal control rats(P0.05).Conclusion Downexpression of MMP-9 in renal glomeluri in diabetic rats may promote the accumulation of extracellular matrix in kidney.Read More
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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