Title: Expression and Significance of VEGF and Type IV Collagen in the Kidney of Diabetic Rats
Abstract:Objective To investigate the relation between the expression of vascular endothelial growth factor (VEGF) and type Ⅳ collagen and the renal lesion of diabetes mellitus in diabetic rats. Methods Wistar...Objective To investigate the relation between the expression of vascular endothelial growth factor (VEGF) and type Ⅳ collagen and the renal lesion of diabetes mellitus in diabetic rats. Methods Wistar rats were divided at random into normal control group(NC group) and diabetic model group(DM group), each group containing 20 animals. The rats models of diabetic mellitus were induced by streptozotocin(STZ). At the 8th week after induction, the expression levels of VEGF and type IV collagen in the kidney tissues in the two groups of rats were detected using immunohistochemistry. At the same time, the renal function of the rats was measured. Results At the 8th week,the expression levels of VEGF and type IV collagen of kidney tissues in DM group was much higher than those in NC group(P0 01),and had positive relation with UAER respectively(r=0 893,P0 01; r=0 726,P0 01). Conclusion The expression levles of VEGF and type IV collagen in the kidney tissues of diabetic rats significantly increased, and had positive relationship with the renal lesion of diabetes mellitus.Read More
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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