Title: Abnormal Expression of Tumor Suppressor Gene P53 in Hepatocellular Carcinoma and its Clinical Significance
Abstract: Objective: To investigate the abnormal expression of tumor suppressor gene p53 in hepatocellular carcinoma and its clinical significance.Methods: The clinical data of patients with pimary liver cancer was retrospectively analyzed from January 2006 to August 2009.The p53 expression in hepatocellular carcinoma,cancer tissue and normal tissue was detected by immunohistochemistry method,and the p53 expression were analyzed in different degree of tumor differentiation.Results: The p53 expression rate in liver cancer group and the adjacent group were 47.5% and 2.5%,respectively.There was no p53 expression in the normal group.The difference among the three groups were significant(x2=6.515,P=0.024).The positive expression rate of p53 in well-differentiated carcinoma was low,but the positive expression of p53 in moderately and poorly differentiated carcinoma was high;the difference was significant(P0.05).The difference was not significant between moderately and poorly differentiated carcinoma(P 0.05).Conclusions: The tumor suppressor gene p53 has high expression in the liver cancer,and its expression is related to degree of tumor differentiatio.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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