Title: The expression and clinical significance of P170 protein and Bcl-2 gene in pancreatic carcinoma
Abstract: Objective To investigate the expression of Pl70 and bcl-2 gene in patients with pancreatic carcinoma and explore its clinical value.Methods The protein expressions of P170 and bcl-2 gene were detected by immunohistochemistry in 81 parafin-embedded specimens from patients with pancreatic carcinoma.Results The positive rates of P170 and bcl-2 protein in pancreatic carcinoma were 67.9% and 72.8% respectively.Before operation the positive expression rates of P170 and bcl-2 gene in chemotherapy group were significantly higher than those in normal pancreatic tissues and non-chemotherapy group.The expression of bcl-2 was related to TNM stage,which had no relation with tumor diameter,lymph node metastasis,the extent of differentiation and type of pathology.However the expression of P170 was only related with the extent of differentiation of tumor cell.The patients' survival time after operation in the group of higher expression of P170 and bcl-2 was shorter than that in the group of lower expression of P170 and bcl-2.Conclusion The pancreas is an organ of primary drug resistance,and chemotherapy can induce MDR.The expression of P170 and bcl-2 is the useful indexes for evaluating prognosis in patients with pancreatic carcinoma.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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