Title: [Expression and clinical significance of E-cadherin and beta-catenin proteins in human laryngeal cancer].
Abstract:OBJECTIVE To investigate the roles of E-cadherin and beta-catenin play in the carcinogenesis and progression of laryngeal carcinoma. METHOD Immunohistochemistry staining (PicTure two steps method) was...OBJECTIVE To investigate the roles of E-cadherin and beta-catenin play in the carcinogenesis and progression of laryngeal carcinoma. METHOD Immunohistochemistry staining (PicTure two steps method) was used to detect E-cadherin and beta-catenin proteins expression in laryngeal carcinomas and normal epithelia around tumors. RESULT In 60 laryngeal carcinomas, the abnormal expression rates of E-cadherin and beta-catenin were 55.00% and 66.67% respectively. The significant relationship was observed between abnormal E-cadherin and beta-catenin expression and differentiation, clinical stage and lymph node metastasis. There was a positive relationship between the expression of beta-catenin and E-cadherin in same sample. CONCLUSION The abnormal expression of E-cadherin and beta-catenin were closely related with differentiation, clinical stage, metastasis in laryngeal carcinoma.Read More
Publication Year: 2008
Publication Date: 2008-05-01
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 3
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