Title: Significance of E-cadherin/catenin adhesion complex expression in nasopharyngeal carcinoma
Abstract:Objective To elucidate the expression pattern of E-cadherin/catenin adhesion complex and its association with pathologic features in nasopharyngeal carcinoma(NPC).Methods Fifty-two non-keratinizing NP...Objective To elucidate the expression pattern of E-cadherin/catenin adhesion complex and its association with pathologic features in nasopharyngeal carcinoma(NPC).Methods Fifty-two non-keratinizing NPC specimens with adjacent non-neoplastic mucosa were examined for E-cadherin,β-CATenin,α-CATenin.Results Abnormal expression rate of E-cadherin,β-catenin and α-catenin in NPCs were 48.1%(25/52),32.7%(17/52) and 34.6%(18/52),respectively,whereas all adjacent non-neoplastic tissues normally expressed these proteins.Difference of expression of E-cadherin,β-catenin and α-catenin between tumor tissues and non-cancerous tissues was statistically significant(P0.01).There were possitive correlations between the expression of E-CAD and α-CAT,β-CAT and α-CAT,E-CAD and β-CAT,respectively.Serum level of anti-Epstain-Barr Virus Viral Capsid Antigen IgA(VCA-IgA) titers in NPCs with normal α-catenin expression was significantly higher than that in NPCs with abnormal α-catenin expression(P0.01).Conclusion Abnormal expression of E-cadherin/β-catenin/α-catenin complex features largely in non-keratinizing carcinoma of nasopharynx,there are positive correlations among the expression of E-cadherin,β-catenin and α-catenin.Downregulation of E-cadherin/catenin adhesion complex does not necessarily favore advanced disease stage or lymph node metastasis in NPC.Read More
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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