Title: Relationship between the expression of E-cadherin-catenins and α-, β-, γ-catenin and the metastasis and prognosis of breast cancer
Abstract:Objective To investigate the relationship between E cadherin,α ,β ,γ catenin expression and clinicopathological features and prognosis of breast cancer. Methods The expression of E cadherin and α , β ...Objective To investigate the relationship between E cadherin,α ,β ,γ catenin expression and clinicopathological features and prognosis of breast cancer. Methods The expression of E cadherin and α , β ,γ catenin in 40 breast cancer specimens was studied by the immunohistochemical method. The relationship between E cadherin,α ,β ,γ catenin expression and clinicopathological characteristics or survival time was analyzed respectively. Results The abnormal expression of E cadherin and α ,β catenin was significantly correlated with lymph nodes and distant metastasis (P0.01, P0.05). The expression of E cadherin and β catenin was also strictly correlated with surival time of breast cancer patients (P0.01). However, when all the four proteins (E cadherin,α ,β ,γ catenin) were analyzed as one group, a significant association was found between the abnormal expression of two or more of these four proteins and the metastasis and prognosis of breast cancer (P0.05).Conclusion Lower expression of E cadherin and β catenin could be used as an important marker of metastasis and prognosis of breast cancer. Moreover, when all the four proteins (E cadherin, α ,β ,γ catenin)are considered together, the accuracy and sensitivity predicting metastasis and prognosis of breast cancer could be increased.Read More
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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Cited By Count: 1
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