Title: Neuroprotective effect of butylphthalide in cerebral ischemic rats
Abstract: Objective To explore the neuroprotective effect of butylphthalide on neurological deficit, cerebral infarct volume and the expression of NF-κB in cerebral ischemic region of rats.Methods 44 rats were randomly divided into ischemia-reperfusion group and butylphthalide-treated group.The butylphthalide-treated group rats were intragastric administrated with butylphthalide( 400 mg·kg- 1·d- 1) everyday before 4 days of MCAO.We made the cerebral ischemia-reperfusion model of rats using an intraluminal monofilament.The neurological deficit scores were made with Zea Longa 5-point scale.TTC staining was used to evaluate the infarct volume.Immunohistochemistry was used to observe the expression of NF-κB.Results( 1) Butylphthalide could significantly decrease the neurological deficit scores in MCAO rats.( 2) Butylphthalide could obviously reduce the brain damage after ischemia-reperfusion,and the infarct volume was significantly reduced by 35.6% in the butylphthalide-treated group after 24 h reperfusion.( 3) Butylphthalide could decrease the expression of NF-κB remarkably after 24 h and 48 h after reperfusion.Conclusion Butylphthalide may reduce the brain damage and the expression of NF-κB.It has neuroprotective effect in cerebral ischemia-reperfusion injury.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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