Title: Neuroprotective effect of butylphthalide preconditioning on cerebral ischemia/reperfusion injury in rats
Abstract: Objective To study the neuroprotective effect of butylphthalide soft capsules(brand name NBP) preconditioning on cerebral ischemia/reperfusion(I/R) injury in SD rats.Methods 48 healthy adult male SD rats were randomly divided into the sham-operative group,focal cerebral ischemia/reperfusion group and NBP preconditioning group,16 rats for each group,and were given gastric lavage for 5 days.The middle cerebral artery occlusion(MCAO) model was established,with ischemia for 2 hours,then reperfusion for 24 hours.The neurological scores were made with Zea Longa 5-point scale.The volume of infarction was measured by TTC staining.The caspase-3and bcl-2 levels were detected by immunohistochemistry technology.Results Compared with the I/R group,rats pretreated with NBP had better neurologic score,less infarction volume,less caspase-3 positive cells and higher bcl-2 level.Conclusion NBP can prevent transient ischemic attack and is neuroprotective against cerebral ischemia/reperfusion injury.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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Cited By Count: 2
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