Title: Effect of angiotensin converting enzyme inhibitors on endothelial function in patients with essential hypertension
Abstract: Objective To evaluate the effects of imidapril and benazapril on blood vessel endothelial function in patients with essential hypertension.Methods By a double blind,double-imitation and randomized trial,30 hypertensive patients were divided into two groups received imidapril and benazapril.The blood pressure,heart rate and plasma NO and ET-1 were measured before and after treatment.Results Affer 10 weeks of treatment,there were significant changes in blood pressure and plasma ET-1(P=0.001).Plasma NO tended to increase,however had no significance(P=0.237).Conclusion long-effective ACEI decrease blood pressure and plasma ET-1 level,the endothelial function was improved particularly.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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