Title: Relationship of VEGF-C expression and lymphatic microvessel density with cervical lymph node metastasis in human laryngeal cancer
Abstract: OBJECTIVE To analyze the relationship of VEGF-C expression,lymphatic microvessel density and cervical lymph node metastasis in human laryngeal cancer,as well as the relationship of VEGF-C expression and lymphatic microvessel density.METHODS VEGF-C expression and lymphatic microvessel density were detected in 47 laryngeal cancer tissues with SP immunohistochemical method. RESULTS The positive rates of VEGF-C in theⅠ,Ⅱ,Ⅲpathological grade level were 55 %,72.22 %, 88.89% respectively,and its expression was significantly correlated with tumor differentiation(P0.05).The positive rates of VEGF-C in lymphatic metastasis group and non-metastasis group were 82.35 % and 60 % respectively,and it had significant difference(P0.05). Lymphatic microvessel density of the Laryngeal cancer tissue in lymph node metastasis group and non- metastasis group were 15.38±5.68 and 10.41±4.23 respectively,and it had significant difference(P0.01). CONCLUSION VEGF-C expression and the lymphatic microvessel density of the laryngeal cancer tissues are closely related to cervical lymph node metastasis.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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