Title: A study on the expression of vascular endothelial growth factor C (VEGF-C)tumor angiogenesis lymphangiogenesis and lymphatic metastasis in human gastric cancer
Abstract: Objective To explore the relationship between the expression of VEGF C?micro vessel density(MVD)?lymphatic microvessel density(LMVD) and lymphatic metastasis in gastric cancer. Methods Immunohistochemistry (SP) was used to detect the expression of VEGF C?CD 31 and lymphatic endothelium marker VEGFR3 in 68 samples of gastric cancer. ResultsThe positive rates of VEGF C in positive lymph node increased significantly than in negative lymph node (70% vs. 30%, P 0 05); LMVD in positive VEGF C was significantly higher than in negative VEGF C (29 6±3 0)vs. (24 4±2 1), P 0 05. Compared with that without lymph node metastasis, LMVD(31 6±2 1)?MVD (40 2±2 3) in positive lymph node increased significantly, P 0 05).Conclusions VEGF C mediates lymphatic metastasis of human gastric cancer by way of lymphangiogenesis. MVD and LMVD were significant predictive factors for tumor lymphatic metastasis.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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