Title: Effects of vascular endothelial growth factor C on lymphatic metastasis of human gastric cancer
Abstract: Objective To explore the relationship among the expression of vascular endothelial growth factor C (VEGF-C),lymphatic micro vessel density (LMVD) and the occurrence of lymphatic metastasis in human gastric cancer.Methods Immunohistochemical method (SP method) was used to detect the expression of VEGF-C and lymphatic endothelium marker vascular endothelial growth factor receptor 3 (VEGFR-3) in 68 resected tissues of gastric cancer,the positive rate of VEGF-C expression and LMVD was calculated.Results The positive rates of VEGF-C expression in specimens with positive lymph node was increased more significantly than that in specimens with negative lymph node (70.05%/30.00%,χ2=9.26,P0.05);the LMVD in specimens with positive VEGF-C was significantly higher than that in specimens with negative VEGF-C expression ( 29.60/21.40, t=2.17,P0.05);compared with specimens without lymph node metastasis,LMVD in specimens with positive lymph node was increased significantly(31.60/20.20,t=3.09,P0.05).Conclusions The expression of VEGF-C has a close relationship with the lymphatic metastasis of human gastric cancer; regulating the lymphangiogenesis in tumor tissues is the main way for VEGF-C to affect the lymphatic metastasis of cancer;LMVD is a significant predictive factor for tumor lymphatic metastasis.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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