Title: Expression of VEGF and its relationship with lymph node metastasis in early gastric cancer
Abstract: Objective To measure the expression of vascular endothelial growth factor (VEGF) family members in early gastric cancer and investigate its correlation with angiogenesis and lymph node metastasis. Methods VEGF expression and microvessel counts in 97 specimens from early gastric cancers were measured by immunohistochemistry method.Correlation of VEGF expression with tumor location, histological type, infiltration and lymph node metastasis were examined. Results No correlation of VEGF expression to tumor location and histology was found(P 0 05). The expression of VEGF A, C was related to venous and lymphatic invasion, as well as lymph node metastasis. The positive rates of VEGF A, C expression were higher in the tumors with invasion and lymph node metastasis(P 0 05).VEGF C positive tumors were mainly located in submucosa(P 0 05). Expression of VEGF A, B, C was related to microvessel counts, and positive expression tumors had higher microvessel counts (P 0 05). Multivariate analysis showed that the expression of VEGF C was an independent factor for lymph node metastasis in early gastric cancer. Conclusion Preoperative determination of VEGF C expression in early gastric cancer is helpful to operative selection and postoperative adjuvant therapy.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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Cited By Count: 1
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