Title: Expression and significance of EGFR,C-erbB_2 and PCNA in multiple primary breast carcinoma tissues
Abstract: Objective:To study the expression of EGFR,C-erbB 2 and PCNA in multiple primary breast carcinoma tissues and to evaluate the prediction significance in occurrence of the second primary carcinoma . Methods: Expression of EGFR,C-erbB 2,PCNA in 34 benign and malignant breast paraffin-embeded specimens ,the difference of the rate and the intensity of positive reaction of EGFR,C-erbB 2,PCNA were checked. Results: The positive rate of EGFR,C-erbB 2,PCNA increased significantly in malignant breast tissues compared with benign breast tissues.The positive intensity of EGFR,C-erbB 2 increased significantly in multiple breast carcinoma tissues compared with tissues of no occurrence of breast carcinoma. Conclusion: The expression of EGFR,C-erbB 2 and PCNA may indicate the proliferating activity of carcinoma cell.The positive intensity of expression of EGFR,C-erbB 2 provided with certain value in prediction of the occurrence of second primary carcinoma.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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