Title: Expression of ErbB-3 and ErbB-4 protooncogene proteins in oral squamous cell carcinoma: a pilot study.
Abstract: To examine the occurrence of ErbB-3 and ErbB- 4 in oral squamous cell carcinoma, as well as investigate statistical correlations between the expression of these protooncogene proteins and clinical and pathological tumor characteristics.Nineteen oral squamous cell carcinomas (SCC) were analyzed using immunohistochemistry.Positive immunostaining for ErbB-3 was found in 13/19 (68%) cases and for ErbB-4 in 10/19 (52%). The intensity of immunostaining for ErbB-3 positive cases was low in 8 (42.1%) and high in 5 (26.3%) cases, and for ErbB-4 ones was low in 6 (31.6%) and high in 4 (21%) of the 19 cases. ErbB-4 overexpression and TNM stage showed a significant correlation (Spearman correlation coefficient=0.467; P=0.04). The Kaplan-Meier analysis showed that the overexpression of ErbB-3 and ErbB-4 had no an influence on survival (P>0.05), but TNM stage was inversely related to survival (P=0.04). There was a significant association between the expression of ErbB-3 and ErbB-4 (chi2=6.193, P=0.037).The results of the present study suggest that c-erbB-4 may contribute to tumor growth and progression.
Publication Year: 2003
Publication Date: 2003-11-05
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 16
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