Title: EXPRESSION AND SIGNIFICANCE OF TGF-Β1,SMAD7 AND VEGF IN ASTROCYTOMA
Abstract: Objective:To investigate the expression and significance of TGF-β1,Smad7 and VEGF in human astrocytoma of brain.Methods:Immunohistochemical method was used to detect the expression of TGF-β1,Smad7 and VEGF in brain astrocytoma and normal brain.Results:The astrocytoma expressed TGF-β1,Smad7 and VEGF in different degree,their expression level increased with the malignant degree of astrocytoma,and the difference had statistical significance(P0.05).Moreover,the expression of Smad7 had positive correlation with VEGF in astrocytoma.Conclusions:TGF-β1,Smad7 and VEGF have close relations with histological grade of astrocytoma,and they can act as valuable indexes to judge the malignant degree of astrocytoma.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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