Title: Study on the expression of VEGF and Ki-67 related to malignant transformation of astrocytoma
Abstract: Objective To explore the expression of vascular endothelial growth factor(VEGF) and Ki-67, and the correlation with malignant transformation of astrocytoma.Metods Using immunohistochemical S-P method the VEGF and Ki-67 were detected in 58 cases of astrocytoma(Ⅰ-Ⅳ grade) and 13 cases of normal brain tissues.Results The expression of both VEGF and Ki-67 had high distinctively difference between different grading of the astrocytoma,and the intensity of the positivity was increased with progression of the malignant degree of the tumor (P0.01).The expression of VEGF correlated to microvascular density.The density of microvessel was enhanced by the occurring and developing of astrotytoma ,and the morphological change of microvessel was also observed.No positive staining for VEGF and Ki-67 was detected in normal brain tissue.Conclusion The overexpression of VEGF and Ki-67 are closely associated with the malignant degree of the astrocytoma,also with the density and the morphological change of microvessel.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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Cited By Count: 1
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