Title: Relevance of vascular endothelial growth factor expression and microvessel density in astrocytoma
Abstract: Objective To study the expression of vascular endothelial growth factor (VEGF) protein in astrocytoma, and to investigate the relevance of VEGF expression and the microvessel density (MVD). Methods Expression of VEGF and MVD in 60 cases of astrocytic tumors were examined with immunohistochemical S P method. The total positive rates of VEGF protein was 63.3%(38/60), and the positive rates increased with progression of pathological grade ( P 0.05). Of all the astrocytoma, the average MVD was 49.21. MVD in grade Ⅱ Ⅲ and Ⅳ astrocytoma were 35.02±5.46, 50.23±11.36 and 66.12±12.58, respectively. The microvessel count in astrocytoma was less than that in anaplastic astrocytoma and glioblastoma multiforme ( P 0.05). A close correlation was found between VEGF expression and MVD in astrocytoma, anaplastic astrocytoma and glioblastoma multiforme. Conclusion VEGF protein and MVD could be considered as biological indicator for malignant potential in brain astrocytoma patients and may be helpful in the understanding of intra tumoral angiogenetic mechanism.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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