Title: Expression of Smad4 and transforming growth factor-β_1, transforming growth factor-β receptor II in cholangiocarcinoma tissue and its biological siginificance
Abstract: Objective To study the expression of Smad4 and transforming growth factor-β_1(TGFβ_1), transforming growth factor-β receptor Ⅱ(TGFβRⅡ) in cholangiocarcinoma tissue and its relationship with the biological behaviour and prognosis of the disease. Methods The expressions of Smad4, TGFβ_1 and TGFβRⅡ were detected by immunohistochemical technique in 47 specimens of cholangiocarcinoma and the normal bile duct tissue adjacent to the tumor. The expressions of Smad4, TGFβ_1 and TGFβRⅡ were compared with the clinical stages and pathological grades of the patients. Results The expression of TGFβ_1 was positive in 36 cholangiocarcinomas (76.6%),which was higher than that in the normal tissue adjacent to the lesion. The positive expressions of Smad4 and TGFβRⅡ were 14(29.8%) and 28(59.6%) in the carcinoma tissues, respectively(P0.05). The expression of TGFβ_1 was related to the clinical stage, metastasis of lymph node and liver of the tumor(P0.05), but not with the histological grade (P0.05). There was positive correlation between TGFβRⅡ expression and the clinical stage(P0.05), but no correlation between the TGFβRⅡ expression and histological grade or metastasis of lymph node and liver(P0.05). The expression of Smad4 was associated with the histological grade, clinical stage and metastasis of lymph node and liver(P0.05). Conclusions The expressions of Smad4, TGFβ_1 and TGFβRⅡ correlate with the histological grading, clinical staging and metastasis of the lymph node and liver in cholangiocarcinoma. Combined detection of Smad4, TGFβ_1 and TGFβRⅡ may be helpful in the determination of the malignant degree and the prognosis of this disease.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot