Title: Research on Expressions of COX-2 and PGE_2 in Substantia Nigra of Rats with Parkinson Disease Treated with Electroacupuncture
Abstract: Objective:To explore the mechanism of electroacupuncture(EA) at Fengfu(DU16)and Taichong(LR3) in Parkinson disease(PD) rats.Methods:32 rats were randomly divided into 4 groups.Model group:the rats were established by subcutaneous injection of rotenone(2 mg/kg,dissolved in sunflower oil,concentration 2 mg/mL)to induce the rats model of PD,once a day,continuous for 28 days.Sham operation group:the rats were injected as the model group,the same parts of the same amount of excluding rotenone sunflower oil.EA group:the rats with PD were treated with electroacupuncture at Fengfu(DU16)and Taichong(LR3) with continuous-wave,2 Hz and 1 mA for 20 minutes,once a day for 14 days.Normal group:the rats received no treatment,normal feeding.The expressions of COX-2 and PGE2 in the substantia nigra were detected by immunohistochemistry.Results:Compared with normal group and sham operation group,the positive neurons counts of the COX-2 and PGE2 were significantly increased in model group(P0.01).After the EA treatment,the expressions of COX-2 and PGE2 in EA group were significantly decreased in comparison with model group(P0.01).Conclusion:EA therapy can play a protective role to PD rats of dopaminergic neurons by reducing the expression of inflammatory mediaors COX-2 and PGE2 in substantia nigra.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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