Title: Effect of Bushen Huoxue Granule( BSHXG) on adenosine A2A receptor in brain of Parkinsons disease( PD) rats
Abstract: Objective To explore the mechanism of treating Parkinson's disease( PD) with Bushen Huoxue Granule( BSHXG). Methods Establishing rat model of PD with 6-hydroxydopamine lesion as medial forebrain bundle the right side of the brain of. 33 PD rats modes were randomly divided into treatment group 18( BSHXG group) and control group 15. Additionally other 15 SD rats were selected in normal group. BSHXG was applied for treatment group once daily for 8 weeks. Physiologic saline was applied for control group and normal group in the same way. Gavage end,observed changes in the rotational behavior of PD rats. After decapitated,Immunofluorescence was used to observe the changes of adenosine A2A receptor in rat brain. Results Rotational behavior of rats in the treatment group was much better improved than in the control group. A2A receptor expression in the treatment group compared with the control group was significantly decreased( P 0. 01). A2A receptor expression in the model group was significantly increased than the normal group( P 0. 01). A2A receptor were not expression in three groups of rats substantia nigra. Conclusion BSHXG can improve the rotational behavior of PD rats,inhibit adenosine A2A receptor expression in PD rat striatum,and has a significant therapeutic effect on the treatment of Parkinson's disease.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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