Title: Ar-He (argon-helium) cryoablation treatment for implanted VX2 liver tumor in rabbit model
Abstract: Objective To introduce an animal model of implanted VX2 liver tumor in rabbits and investigate the therapeutic effect of experimental Ar-He (argon-helium) cryoablation treatment. Methods Two and three weeks after inoculation of VX2 tumor into liver (total 42 lesions), 30 New Zealand white rabbits were separated into two groups as group A (15 rabbits, 22 lesions) and group B (15 rabbits, 20 lesions) and treatment with Ar-He cryoablation. Five weeks after treatment, all rabbits were examined by MSCT and sacrificed with the liver removed for histopathology study. Results The success rate of implantation was 100%, and MSCT demonstrated the blood supply of tumor was plentiful. Five weeks after treatment, MSCT showed the completely necrotic rate of group A and group B was 68% (15/22) and 30% (6/20), respectively. And the metastasis rate of group A and group B was 23% (5/22) and 65% (13/20), respectively. That was consistent with histopathology study. The differences were significant (P0.05 and P0.01, respectively). Conclusion The blood supply to implanted VX2 liver tumor is similar to that of human hepatocellular carcinoma. The implanted VX2 liver tumor is useful animal model for experimental interventional treatment. Ar-He cryoablation treatment can inhibit the growth and metastasis of the tumor, and strong correlation is observed between the therapeutic effect and the opportunity of its treatment.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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