Title: Improvement of the rabbit model bearing vx2 transplanted hepatic carcinoma
Abstract: Objective To establish suitable metastatic rabbit vx2 hepatic carcinoma model,to compare the success rate of different tumor transplanted methods.Methods Thirty New Zealand white rabbits were randomly divided into three groups,10 rabbits in each group.Group 1:Solution of the vx2 carcinoma cells were injected into left liver by syringe needle.Group 2:Solution of the tumor tissue masses was transplanted into liver.Group 3(improvement group):vx2 carcinoma masses were injected into the liver using percutaneous puncture inoculation method.The operation was guided by CT scanner in each group.CT scanning was performed in all experimental animals 2 week after implantation.Results The success rates of transplanted carcinoma were 30%,50% and 90% in group 1,group 2 and group 3 respectively,with the respective ectopic implantation rates of 33%,20% and 0.The difference of success rates between group 1 and group 3 was statistically different.The success rates of single nodule implanted tumor were the highest in group 3(80%) than in group 1(10%) and group 2(20%).The difference between group 1 and group 2,group 1 and group 3 was statistically different.Conclusions It is successful to improve the rabbit model bearing vx2 metastatic hepatic carcinoma.And the method of percutaneous puncture carcinoma masses implantation guided by CT was a good method to set up the hepatic carcinoma models with a high success rates especially rates of single nodule implanted tumor,low ectopic implantation rates and little damage of animals.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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