Title: Rabbit Bearing Uterus VX2 Tumor:Rabbit Model Establishment and the Interventional Therapy
Abstract: Objective To establish the rabbit model bearing VX2 tumor and to investigate the efficiency of interventional treatment.Materials and Methods Thirty New Zealand white rabbits were divided into 3 groups(group A,B and C with 10 rabbits for each group) randomly.The rabbit model was established by implantating VX2 tumor fragments into uterine cavity.DDP(0.5mg/kg),PVA and saline(1ml/kg) were injected through right carotid artery for group A,B and C respectively.Plain and contrast-enhanced MR scan were performed to observe the tumors growth at two weeks after implantation and the tumor necrosis at one week after interventional treatment.Subsequently,the rabbits were sacrificed and the tumors were taken out for pathological examination.Results The tumors were successfully implanted in thirty rabbits uterine cavity with the success rate of 100%.Two rabbits died of hemorrhage and one died of infection after interventional treatment.Round or lobulated neoplasms with isointensity signal were displayed in rabbits uterine cavity on MR plain images.The tumors showed moderate to obviously heterogeneous enhancement or peripheral enhancement on contrast-enhanced images.Angiography showed uterine artery dilated and tumor stain.There was no significant difference of tumor volume change before and after interventional treatment between groupe A and B.There was significant difference of tumor volume and necrosis percentage before and after interventional treatment in goupe C.There was significant difference of the tumor volume and necrosis between groupe C and A or between group C and B.HE stain showed that there was some squamous cell carcinoma tissue under endometrium gland.Conclusion It's convenient and feasible to establish the rabbit VX2 uterus tumor model.The tumors can be observed effectively using MRI,and it is a good model for study of VX2 uterus tumor and fit to interventional treatment.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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