Title: Study of the Synthetic Process of 4-Methyl-5-ethoxyoxazole
Abstract:4-Methyl 5 ethoxyoxazole(Ⅰ),an important intermediate of Vitamin B 6,was synthesized through cycloaddition,hydrolysis,acidification and decarboxylation.Choosing POCl 3/Et 3N/CH 3C 6H 5/(CH 3) 2NCHO as...4-Methyl 5 ethoxyoxazole(Ⅰ),an important intermediate of Vitamin B 6,was synthesized through cycloaddition,hydrolysis,acidification and decarboxylation.Choosing POCl 3/Et 3N/CH 3C 6H 5/(CH 3) 2NCHO as cycloaddition and dehydration agent,when n [CH 3CH(NHCOCO 2Et)CO 2Et]∶ n (POCl 3) ∶ n (Et 3N) = 1 0∶(1 0-1 2) ∶(3 5-4 2),the reaction was carried out for 8 h at 80 ℃ to give 4 methyl 5 ethoxy 2 oxazolecarboxylic acid ethyl ester(Ⅱ) in 91 7% yield.I was successfully prepared from Ⅱ in 88 2% yield through hydrolysis,acidification and decarboxylation in one pot.Analysis of the compounds was done by means of IR and 1HNMR.Read More
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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