Title: Research on 6-bromo-2-bromomethyl-5-hydroxy-1-methyl-indole3-carboxylic acid ethyl ester synthesis technology
Abstract:Using 5-acetyl-1,2-dimethylindole-3-carboxylate,bromine as the raw material,the carbon tetrachloride,the benzoyl peroxide catalytic synthesized and subjected to HPLC tracing detection of 6-bromo-2-bro...Using 5-acetyl-1,2-dimethylindole-3-carboxylate,bromine as the raw material,the carbon tetrachloride,the benzoyl peroxide catalytic synthesized and subjected to HPLC tracing detection of 6-bromo-2-bromomethyl-5-hydroxy-1-methyl-indole-3-carboxylic acid ethyl ester.Using the orthogonal design study to determine the optimal synthesis of process parameters:the ratio of materials 1 for n(5-acetoxy-1,2-dimethyl-indole-3-carboxylic acid ethyl) ∶ n(CTC)=1 ∶ 18.3,the ratio of materials 2 for n(5-acetyl-1,2-dimethyl-indol-3-carboxylic acid ethyl ester) ∶ n(bromine)=1 ∶ 2.84,reaction time 5 h,reaction temperature is 45 ℃.Under optimum conditions a yield of 84.6%,and the purity of more than 98%,to achieve the purpose of optimization.Read More
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot