Title: Synthesis of 2-Br-2methyl-1-(N-methyl-1-piperazine)-1-acetone
Abstract:2-Br-2-methyl-1-(N-methyl-1-piperazine)-1-acetone was synthesized by N-acylation reaction of N-methyl piperazine and 2-Br-2-methyl-propionyl chloride which was synthesized by reacting dichloro sulfoxi...2-Br-2-methyl-1-(N-methyl-1-piperazine)-1-acetone was synthesized by N-acylation reaction of N-methyl piperazine and 2-Br-2-methyl-propionyl chloride which was synthesized by reacting dichloro sulfoxides with 2-Br-2-methyl-propionic acid.The optimum reaction conditions are as follows: the ratio of raw materials of N-methyl piperazine and 2-Br-2-methyl-propionyl chloride was 1:1;the reaction temperature was 12 ℃;the reaction was 4 h;the reaction medium was mixture of water and ethyl acetate.Under the optimal condition,the highest yield of the object compound was 79%.The synthetic product was purified through re-crystallization.And the structure of the product was characterized by TR and 1HNMR.Read More
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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