Title: Synthesis of 3-Formylindole-6-carboxylic Acid
Abstract:Methyl indole-6-carboxylate(3)was obtained from 4-methyl-3-nitrobenzoic acid by esterification with MeOH/H_2SO_4,condensation with N,N-dimethylformide dimethyl acetal(DMFDMA) and reduction with Fe/HAc...Methyl indole-6-carboxylate(3)was obtained from 4-methyl-3-nitrobenzoic acid by esterification with MeOH/H_2SO_4,condensation with N,N-dimethylformide dimethyl acetal(DMFDMA) and reduction with Fe/HAc.3-Formylindole-6-carboxylic acid(1) was synthesized forms 3 with POCl_3/DMF through Vilsmeier reaction.The results show that when the molar ratio of methyl indole-6-carboxylate to DMF and NaOH is 1∶8∶4,the yields of 1 is 54.2%.The structure of 1 was confirmed by IR,()~1H NMR and MS.Read More
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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