Title: Synthesis of 2-Ethoxycarbonyl-3-methyl-4,5-tetramethylenepyrrole
Abstract:N-hydroxyimino ethyl acetoacetate(2) was prepared by oximation of ethyl acetoacetate(1) with NaNO2 in acetic acid.2 was reduced by zinc dust,and then cyclized by addition to cyclohexanone in acetate b...N-hydroxyimino ethyl acetoacetate(2) was prepared by oximation of ethyl acetoacetate(1) with NaNO2 in acetic acid.2 was reduced by zinc dust,and then cyclized by addition to cyclohexanone in acetate buffer solution to obtain 2-ethoxycarbonyl-3-methyl-4,5-tetramethylenepyrrole(3).The appropriate reaction conditions at reflux were as follows: 1 was 100 mmol,n(Zn) ∶n(1) was 2.9 ∶1.0.The total yield was 39% under the conditions.The structure of 4 was characterized by 1H NMR,IR and elemental analysis.3 in yield of 50% was synthesized by one-pot method under the conditions.Read More
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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