Title: Expression and correlation of PTEN,MMP-7 and VEGF in oral squamous cell carcinoma
Abstract: Objective To study the expression and correlation of PTEN , MMP-7 and VEGF in oral squamous cell carcinoma. Methods The expression of PTEN , MMP-7 and VEGF in 40 cases of OSCC tissues and 40 cases of normal oral mucosa tissues were detected using immunohistochemical SP method , respectively. And the correlation among the expression of PTEN , MMP-7 and VEGF in OSCC were analyzed. Results The expression of MMP-7 and VEGF were higher in OSCC than in normal oral mucosa (P 0.05 ) .The positive rate of PTEN protein in OSCC tissues was significantly lower than it in normal oral mucosa tissues (P 0.05 ) . In OSCC , the expression of PTEN was negatively correlated with the expression of MMP-7 and VEGF. Furthermore , the expression of MMP-7 was positively correlated with the expression of VEGF. Conclusion Down-regulation of PTEN expression and up-regulation of MMP-7 , VEGF expression were closely related to the occurrence and development of OSCC. Measurement of the expression of PTEN , MMP-7 and VEGF may have a clinical significance in understanding malignant behavior of OSCC.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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