Title: Expression of tumor suppressor gene PTEN,Cyclin D1,CDK4 in oral squamous cell carcinoma and the analysis of their correlations
Abstract: Objective To detect the expression of PTEN,Cyclin D1 and CDK4 in oral squamous cell carcinoma(OSCC)and analyze the relationship between PTEN,Cyclin D1 and CDK4.Methods Immunohistochemical staining by SP method was used to detect the expression of PTEN,Cyclin D1,CDK4 in 60 cases of OSCC,25 cases of dysplasia,15 cases of simple hyperplasia,and 10 cases of normal oral membrane.Results The negative or low expression of PTEN in OSCC group was 21.8%,which was significantly lower than that in normal,simple hyperplasia and dysplasia group.The positive expression of Cyclin D1 and CDK4 in most of OSCC group were observed,which was 53.3% and 100%,respectively,and was much higher than those in normal,simple hyperplasia and dysplasia group.The negative correlation between PTEN with Cyclin D1 and CDK4 and the positive correlation between Cyclin D1 and CDK4 were observed.Conclusion Our findings suggest that the tumor suppress gene PTEN may play a role in the pathogenesis of OSCC.In OSCC,PTEN may down-regulate the expression of Cyclin D1/CDK4,which results in the suppression of cell growth.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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