Title: Study about expression of proteinase activated receptor-2 in human pancreatic cancer cells and its related mechanism
Abstract:AIM:By observing expression of PAR-2 in human pancreatic cancer cells and cancer tissue adjacent.In order to clear of expression characteristic of PAR-2 in pancreatic cancer and explore relevant mecha...AIM:By observing expression of PAR-2 in human pancreatic cancer cells and cancer tissue adjacent.In order to clear of expression characteristic of PAR-2 in pancreatic cancer and explore relevant mechanism.METHODS: Collect pancreatic specimens and adopting method of SP to detect expression of pancreatic cancer PAR-2 gene.Cultivate pancreas cancer cells and adopting RT-PCR detection expression of PAR-2 gene in pancreatic cancer.RESULTS: PAR-2 mRNA expression of pancreatic cancer group higher than control greup(P0.01).PAR-2 expression has nothing related with age,sex(P0.05).But pancreatic cancer lymph node metastasis is closely positive related to PAR-2 expression,tumor cells distant metastasis,who was significantly higher than those not transfer,the difference was statistically significant(P0.01).CONCLUSION: Occurrence and development of pancreatic cancer is positive correlation of PAR-2.PAR-2 expression in pancreatic cancer has nothing related with age,sex.Occurrence and development of pancreatic cancer is positive correlation of pancreatic cancer lymph node metastasis.Read More
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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