Title: Effects of taurine on apoptosis in neonatal rat cardiomyocytes induced by exogenous hydroxyl free radical
Abstract: Objectives To obserev effects of taurine on apoptosis in neonatal rat cardiomyocytes induced by exogenous hydroxyl free radical. Methods ①The second passage of cultured neonatal rat cardiomyocytes were divided randomly into four groups and were co-cultured with hydroxyl free radical (0.1 mmol·L -1 ) and taurine (30 mmol·L -1 ) in serum-free medium for six hours and 24 hours respectively. The survival ratio and morphology of cardiomyocytes and the percentage of Annexin V +/PI - cells by flow cytometry were evaluated. Results ①The survival ratio of cardiomyocytes significantly decreased with 0.1 mmol·L -1 hydroxyl free radical ( P0.05 vs control) and significantly increased with taurine (30 mmol·L -1 ). ②The percentage of Annexin V +/PI - cells with flow cytometry increased significantly with 0.1 mmol·L -1 hydroxyl free radical and decreased with taurine ( P0.05 ).Conclusions Taurine attenuates apoptosis of neonatal rat cardiomyocytes induced by exogenous hydroxyl free radical.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot