Title: The Role of gliacytes in the pathogenesis of Parkinson's disease
Abstract:Objective To explore the role of gliacytes in the pathogenesis of Parkinson's disease (PD) in the rat models of PD induced by 6-hydroxydopamine(6-OHDA).Methods The 6-OHDA was stereotaxically injected ...Objective To explore the role of gliacytes in the pathogenesis of Parkinson's disease (PD) in the rat models of PD induced by 6-hydroxydopamine(6-OHDA).Methods The 6-OHDA was stereotaxically injected into the right striatum of rats at two sites to produce rat models of PD.Thenwe observed the loss of DA neurons,account the alteration in quantity of microglias and astrocytes by nigral hematoxylin eosin (HE) stain and the expression of tumor necrosis factor-alpha (TNF-α) in the substantia nigra pars compacta and striatum by immunohistochemical stain under optical microscope.Statistical analysis were performed using Student's t-test.The P value less than 0.05 was regarded as statistically significant.Results The microgliocytes and astrocytes were increased in quantity in the right substantia nigra compacta of PD model group( P 0.05).TNF-α was positive expressed in the rightstriatum and right substantia nigra compacta of PD model group and distributed primarily on the activated microgliocytes.Conclusions Gliacytesparticipate the degeneration and death of neurons in the rat model of PD by TNF-α and other cytokines.So the reseach on drugs which can inhibit the activation of microglia cells may provide new methods for the treatment of PD.Read More
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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