Title: The role of microglia and interleukin in the pathogenesis of Parkinson's disease
Abstract:Objective To explore the role of IL-6 and microglia in the pathogenesis of Parkinson's disease (PD),and establish a consistent pattern implicating microglia as the effector for the pathogenesis of PD....Objective To explore the role of IL-6 and microglia in the pathogenesis of Parkinson's disease (PD),and establish a consistent pattern implicating microglia as the effector for the pathogenesis of PD.Methods The 6-OHDA was stereotaxically injected into the right striatum of rats at two sites to fabricate unilateral rats PD model.After two months,we counted the alternation in quantity of microglia and the dopaminegic neurons,ob- served the deletion of the dopaminegic neurons and proliferation of the activated microglia,and observed the expres- sion of IL-6 in the substantia nigra compacta by immunohistoehemical stain under optical microscope.Results The quantity of the dopaminegic neurons in the right substantia nigra compacta of PD model group was obviously deleted,however the microglia was obviously increased.Compared with the sham group and control group,there were significant difference(P0.05).Immunohistochemical stain showed that IL-6 were positively expressed with brown color round the nucleus of microglia.While there was no positive expression in the left substantia nigra compacta in PD model group and the sham-operation group,normal control group.Conclusion When the 6-OH- DA was retrograde absorbed by the neurons,neurons release substances that influence the state of activation of mi- croglia.The activated microglia released immune cytokines IL-6 induced eytotoxic lysis,then cause the neurons chronic degeneracy and necrosis.Read More
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot