Title: Relation between vascular endothelial growth factor expression and clinical pathological character in laryngeal squamous cell carcinoma
Abstract: Objective:To approach the relation between vascular endothelial growth factor(VEGF)expression and clinical pathological character in laryngeal squamous cell carcinoma.Method:Immunohistochemical staining(SP) was used to evaluated the expression of VEGF and microvessel count(MVC) in tumor tissues from 87 patients with laryngeal squamous cell carcinoma.Result:VEGF immune response was mainly localized to the tumor cell cytoplasm,positive rate was 77%.In laryngeal squamous cell carcinoma,the wider the tumor invaded,the stronger VEGF expressed,the fewer the tumor invaded,the weaker VEGF expressed (P 0.05 );The lower the tumor differentiated,the stronger VEGF expressed,the higher the tumor differentiated,the weaker VEGF expressed(P 0.05 );The stronger VEGF expressed,the more MVC were(P 0.01 );The mean MVC in tumor tissues was obviously higher than that in surgical margin tissues(P 0.01 ).Conclusion:In laryngeal squamous cell carcinoma,the expression of VEGF was markedly correlated with tumor stage and differentiation,was positively correlated with MVC.As a result,VEGF may have an important role in the progression of laryngeal squamous cell carcinoma.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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