Title: Expression of vascular endothelial growth factor C and count of lymph vessels in the laryngeal squamous cell carcinoma tissues
Abstract: OBJECTIVE To study the expressionlevel of VEGF-C and the count of lymph vessels (LV) in the laryngeal squamous cell carcinoma and its pericancerous tissues, and to discuss their clinicopathological significance and correlation. METHODS Immunohistochemical method of Envision TM was used for detecting the VEGF-C expression and LV count in the routinely paraffin-embedded sections of specimens of 41 cases with laryngeal squamous cell carcinoma and 20 ones with pericancerous tissues. RESULTS The positive rate and score or LV count was significantly higher in laryngeal squamous cell carcinoma tissues than that in pericancerous tissues (P0.05 or P0.01) . The positive rates and scores of VEGF-C or LV counts were significantly lower in the cases of histological grade Ⅰ, clinical type T1, and no-metastasis of lymphnode than those in the cases of histological grade Ⅲ,clinical type T3 and metastasis of lymphnode in the laryngeal squamous cell carcinoma tissues (P0.05 or P0.01) . The LV count was significantly higher in the cases with positive expression of VEGF-C than in cases with negative expression of VEGF-C (P0.01) , and positive correlation was found between the score of VEGF-C expression and the LV count in the laryngeal squamous cell carcinoma (r=0.47, P0.01) . CONCLUSION The expression of VEGF-C and LV count might be important biological markers for reflecting the progression, biological behaviors and prognosis, and VEGF-C might have enhanced effects on the lymphangiogenesis of laryngeal squamous cell carcinoma.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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