Title: Expression of Survivin and cyclooxygenase-2 and their relationship in cervical carcinoma
Abstract: Objective To investigate the Survivin and Cyclooxygenase-2 (COX-2) expression and their relationship in cervical carcinoma tissues and to investigate the relationship with the genesis and devclopment of cervical carcinoma.Methods The expression of Survivin and COX-2 was assayed by immunohistochemical technique in 60 cervical carcinoma and 30 normal cervical tissue specimens.The relation with its clinical pathology characters were analysed.Results Survivin and COX-2 expression in the tissues of cervical carcinoma [76.7 % (46/60),63.3 % (38/60)] were higher than that in normal cervical tissues evidently [6.7 % (2/30),10.0 % (3/30)] (P < 0.05).The COX-2 expression in cervical carcinoma was positively associated with lymph node metastasis (P < 0.05),but no correlation was found between COX-2 expression and age,clinical stages,grades and invasive depth (P > 0.05).Any correlation between Survivin expression and classical prognostic factors of cervical carcinoma was found.Moreover,these two proteins were positively correlated.Conclusion The Survivin and COX-2 might play important roles in the development of cervical carcinoma.
Key words:
Cyclooxygenase 2; Uterine cervical neoplasms; Apoptosis; Survivin
Publication Year: 2012
Publication Date: 2012-08-28
Language: en
Type: article
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