Title: Expression and correlation of Survivin,Ki-67 and VEGF in cervical carcinoma
Abstract: Objective:To study the relationship between the expressions of Survivin,Ki-67,VEGF in cervical carcinoma and the clinical feature of cervical carcinoma and to observe the correlation between Survivin and Ki-67,VEGF in cervical carcinoma.Methods: Using streptavidin-biotin peroxidase(SP) method,we examined the expression of Survivin、Ki-67and VEGF in 73 cases of cervical carcinoma,25 cases of cervical intraepithelial neoplasia(CIN) and 20 cases of chronic cervicitis.Results: The expression of Survivin,Ki-67 and VEGF presented a growing trend from chronic cervicitis to cervical carcinoma.The expression of Survivin,Ki-67 and VEGF were related to the clinical stages of cervical carcinoma.A positive correlation existed among Survivin and Ki-67,VEGF(r1=0.671,P0.01;r2=0.738,P0.01).Conclusion: The expression of Survivin,Ki-67 and VEGF in cervical carcinoma can reflect the local invasion activity and metastasizing proficiency of cervical carcinoma to a certain extent.They have synergistic effect in development of cervical carcinoma.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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