Title: Determination of a Novel Antidepressant Drug by LC-MS /MS and its Distribution in Rat Tissues
Abstract:Objective To investigate tissue distribution of S-071031B,a novel antidepressant drug,in rats. Methods 24 male SD rats were randomly divided into 4 groups and were given S-071031B at a dose of 20 mg·k...Objective To investigate tissue distribution of S-071031B,a novel antidepressant drug,in rats. Methods 24 male SD rats were randomly divided into 4 groups and were given S-071031B at a dose of 20 mg·kg- 1via oral administration. The samples of plasma and main tissues were collected at 15 min,2 h,6 h and 24 h after administration and a HPLC-MS / MS was developed to determine the concentration of S-071031B in biological samples. Results After po administration of S-071031B at a dose of 20 mg·kg- 1,the highest S-071031B concentration in male rats was found 15 min later in the stomach,intestine and liver,6 h later in the testis,and 2 h later in the heart,spleen,lung,kidney, brain,muscle and blood. The tissue concentration of S-071031B decreased to a very low level after 24 h. Conclusion S-071031B can be quickly absorbed,distributed and eliminated after oral administration in rats and no concentration accumulation can be observed in tissues,suggesting that S-071031B has a good prospect of development.Read More
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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