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'abstract_inverted_index': {'雄ラットおよびイヌに14C-taltirelinを3mg/kg経口投与あるいは1mg/kg静脈内投与した時の吸収,分布,代謝および排泄について検討した.': [0], '1.静脈内および経口投与時の尿中排泄率の比較から算出した吸収率はラットおよびイヌでそれぞれ9および21%であった.また,ラットにおける吸収率は摂餌により約38%低下した.': [1], '2.ラットに経口投与した場合,血漿中放射能濃度は投与後66分で最大(137ng': [2], 'eq./ml)となり,以後,消失半減期119分で減少した.イヌに経口投与した場合,血漿中放射能濃度は投与後90分で最大(431ng': [3], 'eq./ml)となり,半減期146分で減少した.ラットおよびイヌにおける生物学的利用率はそれぞれ3.9および18.5%であった.': [4], '3.ラットおよびイヌでの血漿蛋白結合率はin': [5], 'vivo,in': [6], 'vitroのいずれにおいても12%以下と低かった.': [7], '4.ラットに経口投与後30分~3時間で組織中放射能はピークを示し,この時点で高い組織は消化管以外では肝臓,腎臓,膵臓,肺,血液,皮膚であった.投与後24時間ではこれらの組織内放射能は著しく減少した.また,標的組織である脳における濃度は低く,その消失は遅かった.': [8], '5.いずれの動物においても48時間以内に投与放射能の大部分が排泄され,吸収された放射能の主な排泄経路は腎臓を介した尿中排泄であった.': [9], '6.ラットに静脈内および経口投与した時の投与後24時間までの胆汁中排泄率はそれぞれ5.7および1.7%であった.': [10], '7.ラットおよびイヌにおける血漿中および尿中代謝物としてtaltirelinのacid体およびメチルジヒドロオロチン酸(MDOA)が認められ,ラットとイヌの問で代謝に質的な差は認められなかった.': [11]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2320118737', 'counts_by_year': [{'year': 2020, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-09-19T12:37:58.498873', 'created_date': '2016-06-24'}