Title: Tissue distribution of 3-hydroxyandrost 5-en-17-one succinate (A1998) intralipid after the intravenous injection in rats
Abstract: Objective:To assess the tissue distribution of 3β-hydroxyandrost-5-ene-17-one succinate(A1998) intralipid after iv administration to rats.Methods:After single iv administration of A1998 intralipid 20 mg·kg~(-1),rats were euthanized at certain prescheduled timepoints to collect related rat tissues for the determination of the A1998 concentration-time curve by a pre-column derivation HPLC.Results:The A1998 was mainly distributed in rats'lung,spleen and liver.Compared with the concentration-time curve in the plasma,heart and kidney tissues,the lung,spleen and liver tissues of rats showed significantly higher A1998 concentrations after 15 minutes of iv administration,i.e.,(32.73±3.87),(23.47±8.04) and(14.87±1.63) (μg·g~(-1),) respectively,and longer sustenance of the A1998 concentration after 36 hours of the iv administration [(4.37±2.74),(4.69±2.37) and(8.30±5.96) μg·g~(-1),respectively].No A1998 concentrations were detected in rats'stomach,small intestinal,ovarian,uterine and body fat tissues.Conclusion:The A1998 was rapidly distributed into tissues from the plasma in terms of highly selective affinity to lung,live and spleen tissues.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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