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'datasets': [], 'versions': [], 'referenced_works_count': 3, 'referenced_works': ['https://openalex.org/W1968507822', 'https://openalex.org/W2042561904', 'https://openalex.org/W218365305'], 'related_works': ['https://openalex.org/W560213651', 'https://openalex.org/W4238019484', 'https://openalex.org/W2382395539', 'https://openalex.org/W2355297220', 'https://openalex.org/W2080563441', 'https://openalex.org/W2078679582', 'https://openalex.org/W2050968058', 'https://openalex.org/W200904310', 'https://openalex.org/W1983751608', 'https://openalex.org/W1814249237'], 'abstract_inverted_index': {'14C-SS320Aをラットに単回経口投与(25mg/kg)し,その吸収,分布,代謝,排泄,胎盤通過性および乳汁移行について検討した.': [0], '1.雄性ラットに経口および静脈内投与後の血液中放射能濃度は絶食時に比べて非絶食時でCmaxの低下,Tmaxの遅延,t1/2z,の延長およびAUC0-∞の増加が認められた.また,性差は認められなかった.': [1], '2.In': [2], 'situループ法による雄性ラットでの吸収率は空腸および回腸で高く,SS320Aは小腸全般で吸収されると考えられた.': [3], '3.雄性ラット(絶食)の組織内放射能濃度は投与後0.5時間で大部分の組織で最高放射能濃度を示し,その後,急速に消失し,24時間以降は徐々に消失した.特に高い分布性を示した組織は大脳,眼球,肝臓,腎臓等であったが,投与後120時間までにはそれらの組織は最高放射能濃度の1%以下となった.また,非絶食時でも絶食時とほぼ同様の分布性を示した.しかし,組織からの消失は非絶食時の方がやや遅かった.': [4], '4.In': [5], 'vitroではSS320Aは血漿蛋白とはほとんど結合しなかったが,in': [6], 'vivoでは血漿蛋白との結合が認められた.': [7], '5.血球移行率はin': [8], 'vitroでは23.3~28.0%,in': [9], 'vivoでは17.1~25.1%であった.': [10], '6.雄性ラットに経口投与後1時間の血漿中には主に未変化体で存在し,ついでM1,M3およびM4が検出された.また,尿中では大部分M1,ついでM3であり,未変化体は検出されなかった.血漿および尿ともに食餌の影響はなかった.絶食時のラットに経口投与後1時間の大脳,眼球および肺ではM1がもっとも多く,ついで未変化体,M3,M4の順であり,M2は検出されなかった.肝臓および腎臓では未変化体がもっとも多く,ついで,M3,M4,M2の順であった.非絶食時のラットにおいて大脳,眼球,肺および腎臓では絶食時とほぼ同じ割合であったが,肝臓では未変化体の次にM1が多かった.': [11], '7.雄性ラット(絶食)に経口投与後120時間までの尿中には96.8%,糞中には0.7%,呼気中には0.8%の放射能が排泄された.静脈内投与時も経口投与時と同程度の排泄率を示した.また,性差は排泄にも認められなかった.': [12], '8.雄性ラットに経口投与後48時間までの胆汁には1.3%,尿には95.4%,糞には0.1%が排泄された.': [13], '9.妊娠12日目のラットにおいて胎盤では,投与後0.5時間に,胎児全身では投与後4時間にそれぞれもっとも高い放射能濃度を示した.胎児全身では血漿と比べて放射能の消失は遅く,血漿中放射能濃度が検出限界未満になった投与後24時間でも放射能が検出された.また,妊娠18日目でも投与後4時間以降胎児の全組織で栂獣の血漿中放射能濃度より高く胎児移行性が認められた.投与後48時間では検出された組織の放射能濃度は最高放射能濃度の1%以下となった.': [14], '10.乳汁中放射能濃度は投与後2時間に最高値を示した.投与後4時間以降では血漿中放射能濃度より高い濃度推移を示し,投与後48時間では最高値の約4.5%になった.': [15]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2320056037', 'counts_by_year': [], 'updated_date': '2024-09-12T06:10:21.218248', 'created_date': '2016-06-24'}