Publication Information

{'id': 'https://openalex.org/W1981473788', 'doi': 'https://doi.org/10.2133/dmpk.14.425', 'title': 'Pharmacokinetics of 14C-Telmisartan. (1). Absorption, Distribution and Protein Binding of 14C-Telmisartan after a Single Oral Administration to Rats.', 'display_name': 'Pharmacokinetics of 14C-Telmisartan. (1). Absorption, Distribution and Protein Binding of 14C-Telmisartan after a Single Oral Administration to Rats.', 'publication_year': 1999, 'publication_date': '1999-01-01', 'ids': {'openalex': 'https://openalex.org/W1981473788', 'doi': 'https://doi.org/10.2133/dmpk.14.425', 'mag': '1981473788'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2133/dmpk.14.425', 'pdf_url': 'https://www.jstage.jst.go.jp/article/dmpk1986/14/6/14_6_425/_pdf', 'source': {'id': 'https://openalex.org/S4210239568', 'display_name': 'Drug Metabolism and Pharmacokinetics', 'issn_l': '0916-1139', 'issn': ['0916-1139'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.jstage.jst.go.jp/article/dmpk1986/14/6/14_6_425/_pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5019293895', 'display_name': 'Makoto Shimasaki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210121258', 'display_name': 'Boehringer Ingelheim (India)', 'ror': 'https://ror.org/01xyf9430', 'country_code': 'IN', 'type': 'company', 'lineage': ['https://openalex.org/I1330995197', 'https://openalex.org/I4210121258']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Makoto SHIMASAKI', 'raw_affiliation_strings': ['Kawanishi Pharma Research Institute, Nippon Boehringer Ingelheim Co., Ltd.'], 'affiliations': [{'raw_affiliation_string': 'Kawanishi Pharma Research Institute, Nippon Boehringer Ingelheim Co., Ltd.', 'institution_ids': ['https://openalex.org/I4210121258']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113630214', 'display_name': 'Kazuhiro Yamashita', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210121258', 'display_name': 'Boehringer Ingelheim (India)', 'ror': 'https://ror.org/01xyf9430', 'country_code': 'IN', 'type': 'company', 'lineage': ['https://openalex.org/I1330995197', 'https://openalex.org/I4210121258']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Kazuhiro YAMASHITA', 'raw_affiliation_strings': ['Kawanishi Pharma Research Institute, Nippon Boehringer Ingelheim Co., Ltd.'], 'affiliations': [{'raw_affiliation_string': 'Kawanishi Pharma Research Institute, Nippon Boehringer Ingelheim Co., Ltd.', 'institution_ids': ['https://openalex.org/I4210121258']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020390686', 'display_name': 'Rumi IMANISHI', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210121258', 'display_name': 'Boehringer Ingelheim (India)', 'ror': 'https://ror.org/01xyf9430', 'country_code': 'IN', 'type': 'company', 'lineage': ['https://openalex.org/I1330995197', 'https://openalex.org/I4210121258']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Rumi IMANISHI', 'raw_affiliation_strings': ['Kawanishi Pharma Research Institute, Nippon Boehringer Ingelheim Co., Ltd.'], 'affiliations': [{'raw_affiliation_string': 'Kawanishi Pharma Research Institute, Nippon Boehringer Ingelheim Co., Ltd.', 'institution_ids': ['https://openalex.org/I4210121258']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045117621', 'display_name': 'Kazutoshi Yokoyama', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210121258', 'display_name': 'Boehringer Ingelheim (India)', 'ror': 'https://ror.org/01xyf9430', 'country_code': 'IN', 'type': 'company', 'lineage': ['https://openalex.org/I1330995197', 'https://openalex.org/I4210121258']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Kazutoshi YOKOYAMA', 'raw_affiliation_strings': ['Kawanishi Pharma Research Institute, Nippon Boehringer Ingelheim Co., Ltd.'], 'affiliations': [{'raw_affiliation_string': 'Kawanishi Pharma Research Institute, Nippon Boehringer Ingelheim Co., Ltd.', 'institution_ids': ['https://openalex.org/I4210121258']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048384058', 'display_name': 'Miho KURITANI', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210121258', 'display_name': 'Boehringer Ingelheim (India)', 'ror': 'https://ror.org/01xyf9430', 'country_code': 'IN', 'type': 'company', 'lineage': ['https://openalex.org/I1330995197', 'https://openalex.org/I4210121258']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Miho KURITANI', 'raw_affiliation_strings': ['Kawanishi Pharma Research Institute, Nippon Boehringer Ingelheim Co., Ltd.'], 'affiliations': [{'raw_affiliation_string': 'Kawanishi Pharma Research Institute, Nippon Boehringer Ingelheim Co., Ltd.', 'institution_ids': ['https://openalex.org/I4210121258']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110564887', 'display_name': 'Yoko Oiwa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210121258', 'display_name': 'Boehringer Ingelheim (India)', 'ror': 'https://ror.org/01xyf9430', 'country_code': 'IN', 'type': 'company', 'lineage': ['https://openalex.org/I1330995197', 'https://openalex.org/I4210121258']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Yoko OIWA', 'raw_affiliation_strings': ['Kawanishi Pharma Research Institute, Nippon Boehringer Ingelheim Co., Ltd.'], 'affiliations': [{'raw_affiliation_string': 'Kawanishi Pharma Research Institute, Nippon Boehringer Ingelheim Co., Ltd.', 'institution_ids': ['https://openalex.org/I4210121258']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100514730', 'display_name': 'Takashi Igarashi', 'orcid': 'https://orcid.org/0009-0001-7090-5505'}, 'institutions': [{'id': 'https://openalex.org/I4210121258', 'display_name': 'Boehringer Ingelheim (India)', 'ror': 'https://ror.org/01xyf9430', 'country_code': 'IN', 'type': 'company', 'lineage': ['https://openalex.org/I1330995197', 'https://openalex.org/I4210121258']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Takashi IGARASHI', 'raw_affiliation_strings': ['Kawanishi Pharma Research Institute, Nippon Boehringer Ingelheim Co., Ltd.'], 'affiliations': [{'raw_affiliation_string': 'Kawanishi Pharma Research Institute, Nippon Boehringer Ingelheim Co., Ltd.', 'institution_ids': ['https://openalex.org/I4210121258']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.135, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 15, 'citation_normalized_percentile': {'value': 0.614094, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 81, 'max': 82}, 'biblio': {'volume': '14', 'issue': '6', 'first_page': '425', 'last_page': '431'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11067', 'display_name': 'Colorectal Cancer Treatments and Studies', 'score': 0.9708, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11067', 'display_name': 'Colorectal Cancer Treatments and Studies', 'score': 0.9708, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9659, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10755', 'display_name': 'HER2/EGFR in Cancer Research', 'score': 0.9417, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/telmisartan', 'display_name': 'Telmisartan', 'score': 0.9441372}, {'id': 'https://openalex.org/keywords/jejunum', 'display_name': 'Jejunum', 'score': 0.7108218}], 'concepts': [{'id': 'https://openalex.org/C2779716603', 'wikidata': 'https://www.wikidata.org/wiki/Q733186', 'display_name': 'Telmisartan', 'level': 3, 'score': 0.9441372}, {'id': 'https://openalex.org/C22979827', 'wikidata': 'https://www.wikidata.org/wiki/Q5137311', 'display_name': 'Cmax', 'level': 3, 'score': 0.85829043}, {'id': 'https://openalex.org/C2777056448', 'wikidata': 'https://www.wikidata.org/wiki/Q285166', 'display_name': 'Oral administration', 'level': 2, 'score': 0.7219858}, {'id': 'https://openalex.org/C2776366702', 'wikidata': 'https://www.wikidata.org/wiki/Q185765', 'display_name': 'Jejunum', 'level': 2, 'score': 0.7108218}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.68096626}, {'id': 'https://openalex.org/C125287762', 'wikidata': 'https://www.wikidata.org/wiki/Q1758948', 'display_name': 'Absorption (acoustics)', 'level': 2, 'score': 0.67657065}, {'id': 'https://openalex.org/C2777226302', 'wikidata': 'https://www.wikidata.org/wiki/Q233345', 'display_name': 'Ileum', 'level': 2, 'score': 0.66940594}, {'id': 'https://openalex.org/C2776809568', 'wikidata': 'https://www.wikidata.org/wiki/Q134955', 'display_name': 'Duodenum', 'level': 2, 'score': 0.6458981}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5700946}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.5383604}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.524075}, {'id': 'https://openalex.org/C2779422922', 'wikidata': 'https://www.wikidata.org/wiki/Q1029907', 'display_name': 'Stomach', 'level': 2, 'score': 0.48444322}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.4404683}, {'id': 'https://openalex.org/C2780512811', 'wikidata': 'https://www.wikidata.org/wiki/Q11829360', 'display_name': 'Gastrointestinal tract', 'level': 2, 'score': 0.4230925}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.29085693}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C24890656', 'wikidata': 'https://www.wikidata.org/wiki/Q82811', 'display_name': 'Acoustics', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.2133/dmpk.14.425', 'pdf_url': 'https://www.jstage.jst.go.jp/article/dmpk1986/14/6/14_6_425/_pdf', 'source': {'id': 'https://openalex.org/S4210239568', 'display_name': 'Drug Metabolism and Pharmacokinetics', 'issn_l': '0916-1139', 'issn': ['0916-1139'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2133/dmpk.14.425', 'pdf_url': 'https://www.jstage.jst.go.jp/article/dmpk1986/14/6/14_6_425/_pdf', 'source': {'id': 'https://openalex.org/S4210239568', 'display_name': 'Drug Metabolism and Pharmacokinetics', 'issn_l': '0916-1139', 'issn': ['0916-1139'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 2, 'referenced_works': ['https://openalex.org/W2326493103', 'https://openalex.org/W2475114002'], 'related_works': ['https://openalex.org/W2956455559', 'https://openalex.org/W2788837697', 'https://openalex.org/W2383679175', 'https://openalex.org/W2382221973', 'https://openalex.org/W2355724904', 'https://openalex.org/W2081700576', 'https://openalex.org/W2031501611', 'https://openalex.org/W1998256693', 'https://openalex.org/W1980472199', 'https://openalex.org/W1595866675'], 'abstract_inverted_index': {'Absorption,': [0], 'distribution': [1], 'and': [2, 38, 41, 62, 75, 96, 101, 144, 152, 163, 169, 177, 231], 'protein': [3, 287], 'binding': [4, 288], 'of': [5, 23, 47, 82, 103, 105, 112, 202, 224, 249, 263, 270, 289], '14C-telmisartan': [6, 24, 113, 184, 203], '(BIBR': [7], '277': [8], 'SE)': [9], 'were': [10, 65, 77, 98, 149, 174, 226], 'investigated': [11], 'in': [12, 35, 60, 73, 89, 138, 156, 197, 213, 228, 251, 265, 284], 'rats': [13, 64, 91, 209], 'after': [14, 114, 147, 172, 199, 220, 281, 301], 'a': [15, 243], 'single': [16], 'oral': [17, 21, 115, 200], 'administration.': [18, 221, 282, 302], '1.': [19], 'After': [20], 'administration': [22, 116, 148, 173, 201], '(1': [25, 204], 'mg/kg)': [26, 205], 'to': [27, 131, 206], 'fasted': [28, 106, 207], 'rats,': [29, 40, 107], 'the': [30, 42, 86, 133, 139, 157, 159, 161, 164, 189, 193, 229], 'radioactivity': [31, 225, 245, 250, 264, 271, 290], 'was': [32, 51, 92, 117, 129, 210, 259, 275, 291], 'absorbed': [33, 110, 187], 'rapidly': [34, 253], 'both': [36], 'male': [37, 61, 90, 208], 'female': [39, 63], 'maximum': [43], 'plasma': [44, 70, 286], 'level': [45], '(Cmax)': [46], '184.79-250.55': [48], 'ng': [49], 'eq./ml': [50], 'reached': [52], 'within': [53], '1': [54], 'hr.': [55, 68], 'Elimination': [56], 'half-lives': [57], '(t1/2': [58], '(8-24hr))': [59], 'about': [66, 99], '7': [67], 'The': [69, 80, 94, 109, 125, 237, 247, 283], 'level-time': [71], 'profiles': [72], 'males': [74], 'females': [76], 'similar.': [78], '2.': [79], 'effect': [81], 'food': [83, 122], 'intake': [84], 'on': [85], 'drug': [87], 'absorption': [88, 134], 'investigated.': [93, 211], 'Cmax': [95], 'AUC(0-48hr)': [97], '37%': [100], '77%': [102], 'those': [104], 'respectively.': [108, 154, 179], 'amount': [111], 'thus': [118], 'slightly': [119], 'decreased': [120, 254], 'by': [121], 'intake.': [123], '3.': [124], 'ligated': [126], 'loop': [127], 'method': [128], 'used': [130], 'examine': [132], 'sites.': [135], 'Absorption': [136], 'ratios': [137], 'stomach': [140], 'at': [141, 166, 217, 277, 298], '30,': [142, 167], '60': [143, 168], '120': [145, 170], 'min': [146, 171, 300], '12.5,': [150], '28.3': [151], '24.2%,': [153], 'Those': [155], 'duodenum,': [158], 'jejunum,': [160], 'ileum': [162], 'colon': [165], '43.1-61.9,': [175], '43.9-78.5': [176], '79.4-86.3%,': [178], 'These': [180], 'findings': [181], 'suggested': [182], 'that': [183], 'is': [185], 'readily': [186], 'throughout': [188], 'gastrointestinal': [190, 232], 'tract,': [191, 233], 'except': [192], 'stomach.': [194], '4.': [195], 'Radioactivity': [196, 212], 'tissues': [198, 215, 252], 'most': [214], 'peaked': [216], '0.5': [218], 'hr': [219], 'High': [222], 'levels': [223, 248], 'observed': [227], 'liver': [230], 'including': [234], 'its': [235], 'content.': [236, 246], 'central': [238], 'nervous': [239], 'system': [240], 'showed': [241], 'only': [242], 'low': [244, 276], 'with': [255], 'time.': [256], 'Thus,': [257], 'there': [258], 'no': [260], 'marked': [261], 'accumulation': [262], 'any': [266], 'tissue.': [267], '5.': [268], 'Distribution': [269], 'into': [272], 'blood': [273], 'cells': [274], 'all': [278], 'sampling': [279], 'points': [280], 'vivo': [285], 'very': [292], 'high,': [293], 'being': [294], 'greater': [295], 'than': [296], '99%': [297], '30': [299]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1981473788', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-14T07:01:09.192542', 'created_date': '2016-06-24'}