Title: Effect of Shexiang Wulong Wan on the Pathomorphology and Expresssion of TNF-α and IL-6 in Synovium in the Rats with Adjuvant Arthritis
Abstract: Objective:To observe the effects of Shexiang Wulong Wan(SXWLW) on the pathomorphology and tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in synovium rats with adjuvant arthritis.Method:Adjuvant arthritis(AA)animal model was reproduced.Forty Wistar male rats were divided randomly into 4 groups.model group,normal group treated with normal saline(NS)of 2 mL every day;SXWLW low dose group treated with 1.0 g·kg-1 every day;SXWLW high dose group treated with 2.0 g·kg-1 every day.At the end of the experiment,toe metatarsal joints were collected for pathological examination.The level of TNF-α and IL-6 was checked by immunohistochemical methed.Result:SXWLW low dose and high dose groups,compared with the model group,synovial tissue of damage was significantly reduced;the expression of TNF-α and IL-6 in the SXWLW low dose group and high dose group,compared with model group,decreased(P0.01 or P0.05).Conclusion:SXWLW can reduce the expression of TNF-α and IL-6 in the synovial tissue,therefore it could decrease synovial tissue damage.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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