Title: Effect of Xuanbi decoction on pathology in synocial tissue of rats whit adjuvant arthritis
Abstract: Objective: To explore the therapeutic effects and mechanisms of Xuanbi decoction on adjuvant arthritis(AA) in rats.Methods: The model was induced by intradermal of CFA.The swelling and the arthritis index(AI) were observed at different times respectively.The histopathology changes in synovial tissue were observed by HE method.The expression of VEGF in synovial tissue was detected by immuno-histochemical method.Results: As compared with the model group,the swelling and AI of XB decoction treated group was markedly decreased after treatment(P0.05 or P0.01).The signs were significantly reduced compared with model group(P0.05 or P0.01).Conclusion: XB decoction can reduce the expression of VEGF in the synovium of AA rats and alleviate the inflammatory response,and its mechanism is related to the immuno-regulative function.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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