Title: Therapeutic effect of Qufeng Xitong Wan on adjuvant arthritis in rats
Abstract: AIM To investigate the therapeutic effect of Qufeng Xitong Wan(QFXTW)on rheumatoid arthritis.METHODS The rat model of adjuvant arthritis(AA)was established.The primary and secondary swelling extent in hind paws was detected by using volume testing method and the serum levels of interleukin-1(IL-1)and tumor necrosis factor-α(TNFα)were measured with enzyme-linked immunosorbent assay.RESULTS In AA rats,QFXTW 0.26,0.78 and 2.34 g·kg-1(ig)for 3 d obviously inhibited the right paw swelling,the primary inflammation,and the swelling inhibition rates were 21.4%,36.8% and 65.0%,respectively.QFXTW at the same doses(ig)for 30 d suppressed the left paw swelling,the secondary inflammation,and reduced the scores of polyarticular arthritis markedly.QFXTW 0.78 and 2.34 g·kg-1 also decreased the serum levels of IL-1 and TNFα.CONCLUSION QFXTW has therapeutic effect on experimental AA in rats.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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