Title: Expression of E-cadherin and β-catenin in breast carcinoma and its′ significance
Abstract: Objective To detect the expression of E-cadherin and β-catenin in breast carcinoma and analyze the relationship between E-cadherin and β-catenin and the clinicopathological features. Methods The expression of E-cadherin and β-catenin in breast cancer, paracarcinoma breast tissue, simple mastoplasia and atypical mastoplasia were detected by immunohistochemical method and the results were compared. Results The abnormal expression rates of E-cadherin and β-catenin in breast cancer tissue were 51.9% and 61.1 %,respectively. Abnormal expression of E-cadherin was significantly correlated with histological grade. Abnormal expression of β-catenin was significantly correlated with TNM staging, axillary lymph nodes metastasis and postoperative distant metastasis. COX multiple factor analysis showed that neither E-cadherin nor β-catenin expression was an independent indicator for the prognosis of breast cancer. Conclusions Abnormal expressions of E-cadherin and β-catenin are correlated with occurrence and development of breast carcinoma. Abnormal expressions of E-cadherin and β-catenin are good indicators to judge invasion and metastasis of breast carcinoma.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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