Title: Expressions of CD44v6 and p27 proteins in breast carcinoma and their signifcances
Abstract: Objective To explore the expression and significance of CD44v6 and p27 protions in breast carcinoma.Method The expressions of CD44v6 and p27 proteins in 65 cases of breast carcinoma were detected with S-P immunohistochemical method. Results The expression rates of CD44v6 and p27 protein were 58.4% and 38.4% ,respectively.The expression of CD44v6 protein was positively correlated with histological types and lymph node metastasis of breast carcinoma( P 0.05, P 0.01), and negatively correlated with prognosis ( P 0.01) . There was no evident correlation between CD44v6 expression and histological differentiation ( P 0.05) . The expression of p27 protein was negatively correlated with histological type,differentiation and lymph node metastasis( P 0.05),but was positively correlated with prognosis(P 0.05). Conclusion The expressions of CD44v6 and p27 proteins are correlated with development, metastasis and prognosis of breast carcinoma. Detecting the expression levels of CD44v6 and p27 proteins in breast carcinoma has important reference values in judging infiltration, evaluating prognosis and selecting rational therapeutic method after surgery.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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